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目的探讨１４；１８染色体易位与肝癌的关系。方法采用半套式原位聚合酶链反应技术原位检测５４例肝癌中ｂｃ１－２／ＪＨ融合基因。结果４０例肝细胞癌中未发生染色体易位１０例，检出率２５％；１４例肝胆管癌中未发现ｔ（１４；１８）染色体易位。结论１４；１８染色体易位在肝细胞癌的发生中可能起一定作用，而与肝胆管癌无明显关系。ｍｂｒ和ｍｃｒ区域同为ｂｃ１－２基因在肝细胞癌的两个重要断裂区。
Objective To investigate the relationship between 14;18 chromosome translocation and liver cancer. Methods In situ detection of bc1-2/JH fusion gene in 54 cases of hepatocellular carcinoma was performed using a half-in-situ polymerase chain reaction. Results There were no chromosomal translocations in 10 cases of hepatocellular carcinoma. The detection rate was 25%. No t(14;18) chromosomal translocation was found in 14 cases of hepatocholangiocarcinoma. Conclusion The 14;18 chromosomal translocation may play a role in the occurrence of hepatocellular carcinoma, but it has no relationship with hepato-cholangioma. The mbr and mcr regions are the same as the bc1-2 gene in two important breakage regions of hepatocellular carcinoma.