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目的 为了探讨慢性阻塞性肺病 (COPD)营养状态与甲状腺激素水平的关系 ,以进一步阐明COPD合并营养不良的机制。方法 对 5 3例COPD患者进行营养状况评价 ,同时测定其血清甲状腺素 (T3 、T4 )和促甲状腺激素 (TSH)水平。结果 发现COPD重度营养不良组T3 、T4 显著下降 ,T3 与所有营养参数均呈显著相关性 (P <0 .0 5或P <0 .0 0 1) ,T4 仅与白蛋白有关 (P <0 .0 5 ) ,而TSH与各营养参数均无相关性。结论 甲状腺激素T3 水平与COPD营养状况密切相关 ,COPD低蛋白血症可能与患者甲状腺水平下降而影响蛋白质合成有关。
Objective To explore the relationship between nutritional status of chronic obstructive pulmonary disease (COPD) and thyroid hormone levels to further elucidate the mechanism of malnutrition in COPD patients. Methods Fifty-three patients with COPD were evaluated for nutritional status, and serum thyroxine (T3, T4) and thyroid-stimulating hormone (TSH) levels were measured. The results showed that T3 and T4 of severe malnutrition group were significantly decreased, T3 was significantly correlated with all nutritional parameters (P <0.05 or P <0.01), T4 was only associated with albumin (P <0 .0 5), while TSH had no correlation with nutrition parameters. Conclusions The level of thyroid hormone T3 is closely related to the nutritional status of COPD. The hypoproteinemia of COPD may be related to the decrease of thyroid level and the protein synthesis.