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目的:探究新生儿高胆红素血症血症和反应性血小板增多症之间的相互关系。方法:选择2013年1月~2014年1月三峡大学人民医院收治的250例高胆红素血症患儿和同期随机选择的100例未患高胆红素血症新生儿,比较两组新生儿反应性血小板增多症的发生率,比较高胆红素血症患儿轻度、中度、重度各组间反应性血小板增多症,发生率,比较反应性血小板增多症患儿高胆红素血症组和非高胆红素血症组血小板参数,比较高胆红素血症患儿反应性血小板增多症组和非反应性血小板增多症组黄疸出现时间、高峰胆红素浓度以及住院时间。结果:高胆红素血症组患儿反应性血小板增多症发生率高于非高胆红素血症组,反应性血小板增多症患儿中高胆红素血症组PLT、MPV、PDW水平均高于非高胆红素血症组,反应性血小板增多症患儿黄疸出现时间早于非反应性血小板增多症患儿,高峰胆红素浓度及住院时间高于非反应性血小板增多症组(P<0.05)。结论:新生儿高胆红素血症与反应性血小板增多症之间相互存在不良影响,应当引起临床重视,在治疗过程中应注意预防不良反应的发生。
Objective: To explore the relationship between neonatal hyperbilirubinemia and reactive thrombocythemia. Methods: From January 2013 to January 2014, 250 children with hyperbilirubinaemia and 100 children without hyperbilirubinemia randomly selected from the Three Gorges University People’s Hospital were enrolled in this study. Children with hyperbilirubinemia mild, moderate, severe inter-group reactive thrombocythemia, the incidence of hyperresponsive thrombocytopenia in children with hyperbilirubinemia Hyperlipidemia group and non-hyperbilirubinemia group platelet parameters, hyperbilirubinemia in children with reactive thrombocythemia and non-reactive thrombocythemia in children with jaundice, peak bilirubin concentration and length of stay . Results: The incidence of reactive thrombocythemia in children with hyperbilirubinemia was significantly higher than that in non-hyperbilirubinemia patients. The levels of PLT, MPV and PDW in hyperbilirubinemia patients with hyperbilirubinemia Higher than non-hyperbilirubinemia group, the incidence of jaundice in children with reactive thrombocythemia was earlier than that in non-reactive thrombocytosis, the peak bilirubin concentration and hospital stay were higher than those in non-responsive thrombocythemia group P <0.05). Conclusion: Neonatal hyperbilirubinemia and reactivity thrombocythemia with each other adverse effects, should cause clinical attention, should pay attention to the prevention of adverse reactions in the course of treatment.