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丙酮氰醇在工业上使用较广泛，常有急性中毒发生，为了制订该化合物车间空气卫生标准，我们对上海石化厂丙酮氰醇车间进行了职业流行病学调查，并选用该厂条件基本相同的醋酸车间工人作对照。共空测１２９个样本仅２个未检出，检出率为９８４４％，最高为聚合釜点，平均浓度为１０７ｍｇ／ｍ３，范围００６～１３１９ｍｇ／ｍ３，最低为控制室外平均为０１８８ｍｇ／ｍ３，范围为０～１５４ｍｇ／ｍ３。本调查发现，丙酮氰醇车间工人神经衰弱症候群９９人中检出４８人，检出率为４８４９％，而醋酸车间工人９７人中检出２４人，检出率为２４７４％。两组比较差异非常显著（Ｐ＜００１），γＧＴ检出率为６１％，而对照组检出率为１０３％。差异显著（Ｐ＜００１）。血红蛋白为１４９±１３４ｇ／Ｌ，对照组为１３３±１２１２ｇ／Ｌ，差异非常显著（Ｐ＜００５）。结果提示丙酮氰醇虽是管道化生产，但在合成釜测定点逸出的丙酮氰醇较高。工人接触时间尽管很短，但对工人健康的慢性影响仍然存在。除防治急性中毒外，该化合物的慢性影响不能忽视。
Acetone cyanohydrin is widely used in industry and often has acute poisoning. In order to formulate air hygienic standard for the compound plant, we conducted a survey on the occupational epidemiology of the acetone cyanohydrin plant in Shanghai Petrochemical Plant and selected the conditions of the plant as the same Acetic acid workshop workers as a control. A total of 129 samples were detected only two were not detected, the detection rate was 9844%, the highest polymerization point, with an average concentration of 1 07mg / m3, the range of 0 06 ~ 1319mg / m3, the lowest The control outdoor average is 0188mg / m3, the range is 0 ~ 154mg / m3. The survey found that in the acetone cyanogenin workshop workers, 99 people were diagnosed with neurasthenic syndrome, 48 were detected, the detection rate was 48.49%, while acetic acid workshop workers 97 were detected in 24 people, the detection rate was 24.74%. The difference between the two groups was significant (P <001), the detection rate of γGT was 61%, while that of the control group was 103%. The difference was significant (P <001). The hemoglobin was 149 ± 134g / L, while the control group was 133 ± 1212g / L, the difference was significant (P <005). The results suggest that although acetone cyanohydrin is piped, the acetone cyanohydrin released at the point of the synthesis reactor is higher. Despite the short exposure time of workers, the chronic effects on workers’ health remain. In addition to controlling acute poisoning, the chronic effects of this compound can not be ignored.