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实验证明,70名完成TOPV基础免疫的18～24月龄儿童一轮强化免疫1个月后检测,3型血清抗脊髓灰质炎病毒中和抗体分别为1:45.95、1:124.08和1:34.14;两轮强化免疫1个月后检测,除I-SPVAb(1:57.70)比一轮强化略有增加(P<0.01)外,其余两型抗体未见增加(P>0.50)。据此认为,TOPV基础免疫接种率水平较高,无病例或罕有病例的地区,只要能做好防止漏服的充分准备,采用“扫荡式”一轮强化免疫方法,可节约近50%的人力、物力与经费,可以获得与两轮强化免疫同样地控制Polio发病的满意效果。
Experiments show that 70 completed TOPV basic immunization of 18 to 24-month-old children after a round of boosted one month after the test, type 3 serum anti-polio virus neutralizing antibodies were 1: 45.95,1: 124.08 and 1: 34.14 (P> 0.05). No significant increase was observed in the other two types of antibodies except I-SPVAb (1: 57.70) than the first round of enhancement (P <0.01). Therefore, the TOPV basic immunization rate is high, no cases or rare cases in the region, as long as the leak can be well prepared to prevent the use of “mopping up” an enhanced immunization method can save nearly 50% of the manpower , Material and financial resources, can be obtained with the same two rounds of enhanced immunity to control the incidence of Polio satisfactory results.