作者以前证明肝细胞癌(HCC)患者LAK活性和IFN-γ产生降低;这些参数在肝硬化患者并非异常,提示出现HCC时LAK活性和IFN-γ产生突然降低。本研究对肝硬化患者血清AFP水平和这些免疫参数作前瞻性评价,目的在于预测HCC的出现。 对227例肝硬化患者每1～3个月检测LAK活性和IFN-γ的产生,共23±4个月,继以18个月随访期。男154例,女73例,年龄28～74岁(平均59.6岁)。HCC诊断由血管造 The authors previously demonstrated decreased LAK activity and IFN-γ production in patients with hepatocellular carcinoma (HCC); these parameters are not abnormal in patients with cirrhosis, suggesting a sudden decrease in LAK activity and IFN-γ production in the presence of HCC. This study prospectively evaluated the serum AFP levels and these immune parameters in patients with cirrhosis and aimed to predict the occurrence of HCC. The activity of LAK and the production of IFN-γ were measured every 1-3 months in 227 patients with cirrhosis, for a total of 23±4 months, followed by 18 months of follow-up. There were 154 males and 73 females, aged 28-74 years (average 59.6 years). HCC diagnosis made by vascular