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目的比较重组人酸性成纤维细胞生长因子(rh-a FGF)与碱性成纤维细胞生长因子(b FGF)联合负压封闭引流(VSD)治疗烧伤残余创面的有效性及安全性。方法 47例烧伤残余创面患者,随机分为治疗组(24例)与对照组(23例)。治疗组给予VSD联合rh-a FGF治疗,VSD治疗后继续给予rha FGF换药治疗;对照组则给予VSD联合b FGF治疗,VSD治疗后继续给予b FGF换药治疗。随访8周评估烧伤创面的愈合情况。结果治疗组完全愈合时间、10 d愈合率分别为(14.4±3.7)d、83.3%,优于对照组的(16.7±4.2)d、56.5%(P<0.05);治疗组皮片存活面积(98.7±3.8)%大于对照组的(92.2±1.4)%(P<0.05);两组并发症、瘢痕控制方面比较差异无统计学意义(P>0.05)。治疗组与对照组均未发生明显不良反应。结论 rh-a FGF促进创面愈合、提高皮片移植成活率方面较b FGF更优,在控制创面并发症及瘢痕发生方面,两药无明显差异。
Objective To compare the effectiveness and safety of recombinant human acidic fibroblast growth factor (rh-a FGF) and basic fibroblast growth factor (b FGF) combined with negative pressure closed drainage (VSD) in the treatment of residual burn wounds. Methods 47 patients with burn wounds were randomly divided into treatment group (24 cases) and control group (23 cases). The treatment group was treated with VSD combined with rh-a FGF, and the rha FGF dressing was continued after VSD treatment. The control group was treated with VSD combined with b FGF. After VSD treatment, bFGF dressing was continued. Follow-up 8 weeks to assess the healing of burn wounds. Results The complete healing time of the treatment group was (14.4 ± 3.7) days and 83.3% on the 10th day respectively, which was significantly better than that of the control group (16.7 ± 4.2 and 56.5%, respectively) (P <0.05) 98.7 ± 3.8%) was significantly higher than that of the control group (92.2 ± 1.4%) (P <0.05). There was no significant difference in complications and scar control between the two groups (P> 0.05). No significant adverse reactions occurred in the treatment group and the control group. Conclusion rh-a FGF is more effective than b FGF in promoting wound healing and improving the survival rate of skin grafts. There is no significant difference between the two drugs in controlling wound complications and scarring.