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磺胺是应用广泛的原料药及医药中间体，现生产磺胺的起始原料为乙酰苯胺［１］，成本较高。ＧＩＢｒａｚ［２］等报导了一条采用二苯脲作为起始原料的路线，该路线经氯磺化，氨化，水解三步反应制得，操作繁琐，收率低。我们对其进行了改进，使之更适合于工业生产。原文献中，
Sulfa is a widely used raw material medicine and pharmaceutical intermediates, is the starting material for the production of sulfanilate acetanilide [1], the higher the cost. GIBraz et al. [2] reported a route using diphenyl urea as a starting material. This route was obtained by a three-step reaction of chlorosulfonation, ammoniation and hydrolysis. The operation was cumbersome and the yield was low. We have made improvements to make it more suitable for industrial production. In the original literature,