口服别嘌醇后,在人体大量代谢为氧基别嘌醇(Oxipurinol)。别嘌醇及氧基别嘌醇均能有效地降低尿酸水平,从而控制高尿酸血症。为了便于服用,作者设计了可分散的别嘌醇颗粒剂并与标准片剂进行人体生物利用度的对照研究。将别嘌醇分别制成片剂及颗粒剂,每片(或每份)含别嘌醇300mg。健康受试者4例,于禁食12小时后,给 After oral administration of allopurinol, it is metabolized in large quantities to oxipurinol. Allopurinol and allopurinol can effectively reduce uric acid levels, thus controlling hyperuricemia. For ease of administration, the authors designed a dispersible allopurinol granule and performed a controlled study of its bioavailability with standard tablets. Allopurinol were made into tablets and granules, each tablet (or each) containing allopurinol 300mg. Healthy subjects in 4 cases, 12 hours after fasting, given