羰基化合物与原甲酸三乙酯生成缩酮后加入莽草酸甲酯(2),在酸催化下能温和、迅速地制备2的缩酮化物,即二(口恶)霉素类似物,用此法制备了化合物4～10,并由~1HNMR 推测了10α和10β的绝对构型。本文报道的方法可方便地引入1,2-和1,3-二醇的常用保护基。 The carbonyl compound and triethyl orthoformate are converted to ketal and methyl shikimic acid (2) is added to produce a mild and rapid 2-ketal, ie, Compounds 4 ~ 10 were prepared by the method and the absolute configuration of 10α and 10β was deduced from ~ 1HNMR. The methods reported here conveniently introduce common protecting groups for 1,2- and 1,3-diols.