胸苷激酶1(TK1)是一种嘧啶补救途径的激酶,能催化脱氧胸苷磷酸化为一腺胸苷酸,与细胞周期调控和细胞增殖密切相关。多项实验证明,TK1可用于健康体检、肿瘤早期筛查、常规检测、疗效监视和预后等方面,是一种灵敏有效地评估人体肿瘤增长的标志物。本综述概述了近年关于TK1临床应用的新进展。 Thymidine kinase 1 (TK1) is a kinase of the pyrimidine salvage pathway that catalyzes the phosphorylation of deoxythymidine into adenythymidylate, which is closely related to cell cycle regulation and cell proliferation. A number of experiments have shown that TK1 can be used as a sensitive and effective marker to evaluate the growth of human tumors in healthy physical examination, early tumor screening, routine testing, curative effect monitoring and prognosis. This review summarizes the recent advances in the clinical use of TK1.