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65例晚期胃癌患者,按随机配对法分为两组,进行前瞻性的化疗临床观察,两组基本情况相似,治疗组以大剂量短疗程5 FU治疗,给药方法为每天静滴5 FU1000mg,连续15天为一疗程,两疗程的间隔为4周;对照组静脉注射5 FU500mg,d_(1-3),MMC 6 mg,d_1,每周重复,4周为一疗程,疗程间隔2周,治疗结果示有效率分别为42.4％(14/33)与28.1％(9/32)(P<0.05),有效病例的中位生存期分别为7个月与6个月,均能耐受毒性,说明5 FU大剂量短疗程方案为一个有效、低毒、易得与廉价的化疗方案。
Sixty-five patients with advanced gastric cancer were divided into two groups according to the randomized pairing method. Clinical observation of prospective chemotherapy was performed. The basic conditions of the two groups were similar. The treatment group was treated with a large-dose, short course of 5 FU, and the administration method was intravenous infusion of 5 FU 1000 mg per day. 15 consecutive days for a course of treatment, the interval between the two courses is 4 weeks; control group intravenously 5 FU 500mg, d_ (1-3), MMC 6 mg, d_1, repeated weekly, 4 weeks for a course of treatment, treatment interval of 2 weeks, The treatment efficiency was 42.4% (14/33) and 28.1% (9/32) respectively (P<0.05). The median survival time of effective cases was 7 months and 6 months, respectively. Both were tolerant to toxicity. , Description 5 FU large dose short course program is an effective, low toxicity, easy to get and cheap chemotherapy.