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目的:探讨子宫颈上皮内瘤变(CIN)的发生,发展与转归。方法:回顾性分析本院2007年1～12月间液基细胞学检查ASC-US(意义不明确的鳞状上皮细胞)以上的阳性患者行阴道镜检查并多点取活检行组织病理学检查结果。病理诊断采用三级分类法,即CINⅠ、CINⅡ、CINⅢ,其中原位癌归入CINⅢ中,记作CINⅢ/CIS。结果:CINⅠ223例,HPV阳性率为65.0%,平均年龄32.9岁;CINⅡ88例,HPV阳性率为78.4%,平均年龄36.7岁;CINⅢ49例,HPV阳性率81.6%,平均年龄43.3岁。结论:处于性活跃期的中青年女性是宫颈CIN的高发人群;HPV与CIN之间有极为密切的关系。正确诊断子宫颈上皮内瘤变,辨别HPV感染,指导临床早期治疗CIN,对预防浸润癌的发生有重大意义。
Objective: To investigate the occurrence, development and prognosis of cervical intraepithelial neoplasia (CIN). Methods: A retrospective analysis of our hospital from January 2007 to December 2007 liquid-based cytology ASC-US (undefined squamous epithelium) positive patients colposcopy and multi-biopsy histopathological examination result. Pathological diagnosis using three classifications, namely CIN Ⅰ, CIN Ⅱ, CIN Ⅲ, including carcinoma in situ classified CIN Ⅲ, recorded as CIN Ⅲ / CIS. Results: In CINⅠ223 cases, the positive rate of HPV was 65.0% with an average age of 32.9 years. In CINⅡ88 cases, the positive rate of HPV was 78.4% with an average age of 36.7 years. CINⅢ was 49 cases with HPV positive rate of 81.6% with an average age of 43.3 years. Conclusions: The middle-aged and young women who are in the sexual active stage are the high incidence of CIN in the cervix. There is a very close relationship between HPV and CIN. Correct diagnosis of cervical intraepithelial neoplasia, HPV infection, early clinical guidance CIN, to prevent the occurrence of invasive cancer is of great significance.