在恶性肿瘤未被发现之前,病人首先表现出皮肤病征,这在恶性肿瘤病来说并不常见。但在国内外文献中报道,皮肤病合并恶性肿瘤的发生率在6.7～90.50％之间。1863年 Wagner 首先报告皮肌炎合并恶性肿瘤,1890年 Lesr 和 Trelat 最早报道 Lesr—Trelat 综合征的出现,暗示有恶性肿瘤 Before the malignancy was discovered, the patient first showed a dermatological sign, which is not common in malignancy. However, it is reported in domestic and foreign literature that the incidence of dermatological malignancies is between 6.7 and 90.50%. 1863 Wagner first reports dermatomyositis with malignancy. In 1890, Lesr and Trelat first reported the appearance of Lesr-Trelat syndrome, suggesting malignancy.