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目的:对依那普利与贝那普利分别联合小剂量氢氯噻嗪治疗轻中度高血压的疗效进行药物经济学评价。方法:选取2007年5月～2008年10月,在我院门诊确诊的原发性轻中度高血压患者98例,随机分为2组:A组给予依那普利+氢氯噻嗪,B组给予贝那普利+氢氯噻嗪,4周治疗后统计两组治疗方法的费用和临床疗效,计算成本-效果比和增量成本-效果比。结果:两组治疗费用分别为73.36元和112.56元,总有效率分别为75.00%和77.08%,成本-效果比分别为98和146,两组间疗效和不良反应差异无统计学意义(P>0.05)。结论:依那普利组能减轻患者经济负担,且获得较好的疗效。
OBJECTIVE: To evaluate the efficacy of enalapril and benazepril combined with low-dose hydrochlorothiazide in the treatment of mild to moderate hypertension. Methods: From May 2007 to October 2008, 98 patients with primary mild to moderate hypertension diagnosed in our hospital were randomly divided into 2 groups: group A received enalapril + hydrochlorothiazide, group B received Benazepril + hydrochlorothiazide, after 4 weeks of treatment, the cost and clinical efficacy of the two treatment methods were calculated, and the cost-effectiveness ratio and incremental cost-effectiveness ratio were calculated. Results: The cost of treatment was 73.36 yuan and 112.56 yuan respectively. The total effective rates were 75.00% and 77.08% respectively. The cost-effectiveness ratios were 98 and 146 respectively. There was no significant difference in efficacy and adverse reactions between the two groups (P> 0.05). Conclusion: Enalapril group can reduce the economic burden of patients, and get better curative effect.