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目的:探讨血浆N端脑钠肽前体(NT-proBNP)与和肽素检测用于急性脑出血患者中的临床效果。方法:随机选择2014年5月至2016年2月广州市从化区中医院收治的30例急性脑出血患者为观察组,同期选取30例健康体验人群作为对照组,比较两组人员的血浆NT-proBNP与和肽素检测、格拉斯哥昏迷评分(GCS)等。结果:观察组的血浆NT-proBNP、和肽素水平等明显比对照组高,差异具有统计学意义(P<0.05);其中血浆NT-proBNP、和肽素水平等和脑出血量呈正相关(P<0.05);观察组中,与少量以及中量出血患者相比,大量出血者的NT-proBNP浓度指数更高(P<0.05)。结论:对急性脑出血患者血浆NT-proBNP与和肽素检测能反映出脑出血患者病情的严重程度。
Objective: To investigate the clinical effect of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) and copeptin in patients with acute cerebral hemorrhage. Methods: Thirty patients with acute cerebral hemorrhage admitted from Conghua Hospital of Traditional Chinese Medicine from May 2014 to February 2016 were selected as observation group and 30 healthy people as control group. The plasma NT- proBNP and copeptin testing, Glasgow coma score (GCS) and so on. Results: The plasma levels of NT-proBNP and Copeptin in the observation group were significantly higher than those in the control group (P <0.05), and the plasma levels of NT-proBNP and Copeptin were positively correlated with the amount of cerebral hemorrhage P <0.05). In the observation group, the NT-proBNP concentration index of the large number of hemorrhages was higher than that of the small amount and middle amount of hemorrhage patients (P <0.05). Conclusion: The plasma levels of NT-proBNP and copeptin in patients with acute cerebral hemorrhage can reflect the severity of patients with cerebral hemorrhage.