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作者1977～1989年间收治了3例(35～49岁、均为男性)脐尿管癌,就本病与癌胚抗原(CEA)的关连性进行研究。采用单克隆抗体ABC法行免疫组织化学观察表明,CEA弥散在癌细胞的胞体内1例。集聚在癌细胞腺腔面的小皮缘2例。术前采用RIA固相法测定2例血清CEA高于正常,分别为3.5ng/ml与5.6ng/ml(正常值小于2.5),术后恢复正常,提示血清CEA作为本病肿瘤标记物的可能性。术后3例分别采用MFC疗法(MMC4mg,5-Fu500mg,阿糖胞苷20mg静点)10次、18次和30次,随访2年4月～12年3月无复发。本研究表明,若明确CEA与本病自然病程的关连,那么组织学的CEA阳性所见及血清CEA的测定
From 1977 to 1989, 3 cases (35 to 49 years old, all males) of urachal cancer were treated. The relationship between this disease and carcinoembryonic antigen (CEA) was studied. Immunohistochemical observation using monoclonal antibody ABC showed that CEA diffused in the cytoplasm of cancer cells in 1 case. There were 2 cases of small skin margins gathered on the surface of the adenocarcinoma of the cancer cells. Preoperative RIA was used to determine the serum CEA levels in the 2 patients with 3.5 ng/ml and 5.6 ng/ml (normal value less than 2.5). The postoperative recovery was normal, suggesting that serum CEA may serve as a tumor marker for this disease. Sex. 3 cases were treated with MFC (MMC4mg, 5-Fu500mg, cytarabine 20mg) 10 times, 18 times and 30 times respectively. There was no recurrence in the follow-up period of 2 years from April to March of the year. This study shows that if the relationship between CEA and the natural course of the disease is clear, then the histological CEA positive findings and serum CEA determination