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普萘洛尔治疗婴幼儿血管瘤(IH)疗效显著,但是安全性问题尚存争议。该文作者将2010—2013年法国多家医疗中心就诊的严重血管瘤患儿纳入研究,主要包括位于咽喉部可能会引起窒息的IH,位于眼眶可能会引起弱视的IH,病变范围大,表面溃疡出血的IH,对这些IH给予口服普萘洛尔治疗,平均治疗时间为198 d,治疗剂量为2mg/(kg·d)。结果:纳入研究的906例患儿平均年龄114 d,治疗前,72.4%患儿出现功能影响,40%表现严重溃疡,43例患儿接受过其他治疗。治疗中81例患儿出现药物
Propranolol is effective in treating infantile hemangiomas (IH), but safety issues remain controversial. The authors enrolled children with severe hemangiomas from 2010 to 2013 at several medical centers in France, including IH that may cause asphyxiation in the throat, IH in the orbit that may cause amblyopia, large lesions, and ulceration on the surface Hemorrhagic IH, oral propranolol oral administration of these IH, the average treatment time was 198 d, the therapeutic dose of 2mg / (kg · d). RESULTS: The average age of 906 children enrolled in the study was 114 days. Before treatment, 72.4% of children had functional effects, 40% had severe ulcers, and 43 had other treatment. 81 cases of children in the treatment of drugs