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三氯唑核甙(病毒唑)是一种新的核甙类广谱抗病毒药物,其化学名称为1-β-D 呋喃核糖基-1,2,4-三氮唑-3-羧酰胺,结构式为:美国加州核酸研究所1972年首先报道,但还没有正式生产。1973年后,湖北省医药工业研究所、中国医学科学院抗菌素研究所和上海第六制药厂协作,分别完成了合成路线、体内外抗病毒作用以及中试放大和工艺改革等方面的研究工作,并在上海、北京、武汉等地进行临床试用。
Trichlorethylene ribavirin (ribavirin) is a new broad spectrum of nucleoside antiviral drugs whose chemical name is 1-β-D ribofuranosyl-1,2,4-triazole-3-carboxamide , The structure is: California Institute of nucleic acids first reported in 1972, but not yet formally produced. After 1973, Hubei Institute of Pharmaceutical Industry, Institute of Antibiotics of Chinese Academy of Medical Sciences and Shanghai No. 6 Pharmaceutical Factory collaborated to complete the research work on synthesis route, antiviral effect in vivo and in vitro, amplification of pilot scale and process reform, etc. In Shanghai, Beijing, Wuhan and other places for clinical trials.