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异山梨醇(Isosorbide)是一口服有效的渗透性利尿药。作者以不同的剂量(分别为0.25,0.5及1.0克/公斤体重)和给药方法(1克每天1次或0,5克/公斤体重每天2～3次)对29例受试者进行研究,其中20名单服此药,另9名先一次口服异山梨醇1.5克/公斤体重,一周后再服双氢氯噻嗪50毫克,第3周两药合用。为了排除排尿活动的昼夜变动对结果的影响,采用了自身对照的方法。结果表明,异山梨醇具有明显的利尿作用,能增加水和渗透克分子(Osmolar)的排出量,剂量愈大,反应愈强。
Isosorbide is an oral effective diuretic. The authors studied 29 subjects at various doses (0.25, 0.5 and 1.0 g / kg body weight, respectively) and administration methods (1 g daily or 0,5 g / kg body weight 2 to 3 daily) , Of which 20 were given the drug alone, and the other 9 first oral isosorbide 1.5 g / kg body weight, one week after serving hydrochlorothiazide 50 mg, the first two weeks of the two drugs combined. In order to rule out the diurnal changes in urinary activity on the results, using a self-control approach. The results showed that isosorbide has a significant diuretic effect, can increase the water and osmolar (Osmolar) emissions, the greater the dose, the stronger the response.