体重超出理想值的20％被定义为肥胖。能量的摄取大于消耗,使脂质过多地蓄积于脂肪组织造成肥胖。目前用以减肥的药物主要是食欲抑制剂,通常结合限制饮食力图减少热卡摄取。大多数食欲抑制剂通过调节中枢神经系统内源性的生物胺水平而起作用。这些药物由于副作用、成瘾性和耐受性限制了其长期服用;一旦停用,又会造成回跳性的饮食增多。本文介绍的是一个新的柠檬酸衍生物类食欲抑制剂。合成反-乌头酸二钾盐在KOCl水溶液中低温氧化成苏-氯柠檬酸的三钾盐(Ⅰ), Body weight over 20% of ideal is defined as obesity. Energy intake is greater than consumption, so that too much lipid accumulation in adipose tissue caused by obesity. The drugs currently used to lose weight are mainly appetite suppressants, often in combination with dietary restriction to reduce calorie intake. Most appetite suppressants work by regulating endogenous levels of biogenic amines in the central nervous system. These drugs limit their long-term use due to side effects, addictiveness and tolerability; once discontinued, they can cause a rebounding diet. This article describes a new citric acid derivative appetite suppressant. Synthesis of trans-aconitic acid dipotassium salt in KOCl aqueous solution at low temperature oxidation of tri-potassium citrate tripotassium salt (Ⅰ),