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关于动脉粥样硬化的病因和发病原理有许多学说。六十年代以来,有些学者提出,动脉壁平滑肌细胞溶酶体内水解酶含量相对不足,不能全部降解进入细胞内过多的胆固醇及其酯,造成脂质堆积,可能是粥样硬化的病因之一。一般认为,凡细胞内经细胞化学测定含有酸性磷酸酶的小体,便是溶酶体。一些研究证明,动脉粥样硬化时,动脉壁平滑肌细胞内溶酶体含量增多,有人还观察到,溶酶体的活性和数量与脂质的改变、分布相一致。
There are many theories about the etiology and pathogenesis of atherosclerosis. Since the 1960s, some scholars have suggested that the content of lysozyme in the arterial wall smooth muscle cells is relatively insufficient, and they cannot be fully degraded into excessive cholesterol and esters in the cells, resulting in lipid accumulation, which may be one of the causes of atherosclerosis. . It is generally believed that all cells containing cytoplasmic acid phosphatase in cells are lysosomes. Some studies have shown that when atherosclerosis occurs, the content of lysosomes in the smooth muscle cells of arterial walls increases, and it has also been observed that the activity and quantity of lysosomes are consistent with the changes and distribution of lipids.