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目的:检测放疗后出现认知功能障的鼻咽癌患者血清白介素-6(IL-6)水平在放疗前、后的变化,分析血清IL-6水平与认知功能障碍的相关性。方法:108例鼻咽癌患者放疗周期结束后通过蒙特利尔认知功能评估(MoCA)量表进行认知功能评估,根据评分结果分为放疗后不伴认知功能障碍组52例和伴认知功能障碍组56例。通过酶联免疫吸附法(ELISA)分析两组患者放疗前、后血清IL-6水平的差异;Pearson相关分析放疗后出现认知功能障碍的鼻咽癌患者血清IL-6水平与患者MoCA评分的相关性。结果:鼻咽癌放疗后出现认知功能障碍患者放疗后血清IL-6水平显著高于不伴认知功能障碍患者(P<0.001);认知功能障碍患者血清IL-6水平与其MoCA评分呈显著负相关(r=-0.86,P<0.001)。结论:鼻咽癌患者放疗后血清IL-6水平在伴认知功能障碍者中显著升高并与认知功能障碍具有相关性,血清IL-6水平对鼻咽癌患者放疗后出现认知功能障碍具有潜在提示价值。
Objective: To detect the changes of serum interleukin-6 (IL-6) level in patients with cognitive dysfunction after radiotherapy before and after radiotherapy, and to analyze the correlation between serum IL-6 level and cognitive dysfunction. Methods: One hundred and eighty nasopharyngeal carcinoma patients were evaluated for cognitive function by the Montreal Cognitive Function Assessment (MoCA) scale after the end of radiotherapy cycles. According to the score, 52 patients with cognitive impairment without cognitive impairment 56 cases of disorder group. The difference of serum IL-6 level before and after radiotherapy was analyzed by enzyme-linked immunosorbent assay (ELISA). The Pearson correlation analysis showed that serum IL-6 level in patients with cognitive dysfunction after radiotherapy and MoCA score Correlation. Results: Serum levels of IL-6 in patients with cognitive dysfunction after radiotherapy for radiotherapy of nasopharyngeal carcinoma were significantly higher than those in patients without cognitive impairment (P <0.001). The levels of serum IL-6 and MoCA in patients with cognitive impairment Significant negative correlation (r = -0.86, P <0.001). CONCLUSIONS: Serum IL-6 levels in patients with nasopharyngeal carcinoma after radiotherapy are significantly elevated in patients with cognitive impairment and are associated with cognitive dysfunction. Serum IL-6 levels have cognitive function after radiotherapy in patients with nasopharyngeal carcinoma Obstacles have a potential hint value.