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目的探讨恶性脑胶质瘤术后行放疗联合替莫唑胺化疗的疗效。方法选取52例恶性脑胶质瘤术后患者,随机分为两组,每组各26例。1组行放疗,每次2Gy,5次/周,共30次,总剂量60Gy。2组行放疗联合替莫唑胺化疗,除给予1组相同的放疗外,还接受替莫唑胺同期化疗,化疗完毕比较两组患者的整体疗效及生活质量。结果 2组完全缓解7例,部分缓解11例,有效率为69.23%;1组完全缓解4例,部分缓解6例,有效率占38.46%。两组疗效比较差异有统计学意义(P<0.01)。结论替莫唑胺联合放疗方案治疗术后恶性脑胶质瘤优于单纯放疗,值得临床推广。
Objective To investigate the effect of radiotherapy combined with temozolomide chemotherapy after malignant glioma surgery. Methods Fifty-two patients with malignant glioma were randomly divided into two groups, with 26 cases in each group. Group 1 radiotherapy, each 2Gy, 5 times / week, a total of 30 times, the total dose of 60Gy. Two groups of radiotherapy combined with temozolomide chemotherapy, in addition to given a group of the same radiotherapy, but also received temozolomide concurrent chemotherapy, chemotherapy was completed compared the overall efficacy and quality of life of the two groups of patients. Results In group 2, 7 cases were completely relieved, 11 cases partially relieved, and the effective rate was 69.23%. In group 1, 4 cases were completely relieved, 6 cases partially relieved, and the effective rate was 38.46%. The difference between the two groups was statistically significant (P <0.01). Conclusion Temozolomide combined with radiotherapy for postoperative malignant glioma is superior to radiotherapy alone, which is worthy of clinical promotion.