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目的分析阿奇霉素对鼻内镜术后康复治疗的作用及机制。方法 2015年6月—2017年5月,于该院收治的行鼻内镜手术治疗的患者中选取60例,两组均接受鼻内镜鼻窦手术治疗,术后给予对照组常规治疗,在对照组基础上给予观察组患者阿奇霉素治疗,对比两组治疗效果。结果观察组患者ICAM-1、IL-8、IL-1、TNF-α以及C反应蛋白等指标水平均优于对照组,术腔黏膜水肿消退时间、术腔完全上皮化时间、术腔清洁时间均短于对照组,差异有统计学意义(P<0.05);观察组术后术腔粘连发生率、感染发生率分别为3.33%、3.33%,低于对照组的20.00%、23.33%,差异有统计学意义(P<0.05)。结论阿奇霉素在鼻内镜术后康复治疗中的应用效果显著。
Objective To analyze the effect and mechanism of azithromycin on rehabilitation therapy after endoscopic sinus surgery. Methods From June 2015 to May 2017, 60 patients undergoing endoscopic sinus surgery in our hospital were enrolled. Both groups were treated with endoscopic sinus surgery and were given conventional therapy after operation. In the control group, Based on the observation group patients given azithromycin treatment, the two groups were compared. Results The levels of ICAM-1, IL-8, IL-1, TNF-α and C-reactive protein in the observation group were better than those in the control group. The mucosal edema subsided time, the complete epithelialization time, (P <0.05). The incidence of intraoperative cavity adhesion and infection in the observation group were 3.33% and 3.33% respectively, which was lower than that of the control group (20.00% and 23.33%, respectively), and the difference was statistically significant There was statistical significance (P <0.05). Conclusion Azithromycin has a significant effect in rehabilitation treatment after endoscopic sinus surgery.