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去纤维蛋白多核苷酸(defibrotide)是从哺乳动物肺提取的一种多聚脱氧核糖核酸钠盐,文献中曾称它为P组份,到1981年才被命名为defibrotide(以下简称DEF).意大利学者Niada,R.等在七十年代末发现DEF具有纤溶作用,八十年代初又发现DEF有抗血栓效应.近年来,人们对DEF的抗血栓效应和纤溶作用、以及防治急性心肌梗塞的兴趣与日俱增,在心血管疾病研究领域又出现了一个新的分枝. 一、DEF的生化性质和药代动力学 DEF是由60个脱氧核苷酸组成的单股DNA,分子量约20,000,其中磷酸占9%,胸腺嘧啶占10.55%,胞嘧啶占6.4%,腺嘌呤和鸟嘌呤分别占9%和7.7%.尽管有关DEF的制备方法未见公开报
Defibrotide, a poly-sodium deoxyribonucleic acid extracted from the lungs of mammals, has been referred to as the P component in literature and was not named defibrotide (DEF) until 1981. In the late seventies, Italian scholar Niada, R., et al found that DEF had fibrinolytic activity and that DEF had antithrombotic effect in the early 1980s. In recent years, people have been shown to have anti-thrombotic effects and fibrinolytic effects on DEF and to prevent and treat acute myocardial infarction There is a growing interest in infarction and a new branch in cardiovascular disease research.1 DEF Biochemical Properties and Pharmacokinetics DEF is a single strand of 60 deoxynucleotides with a molecular weight of about 20,000, 9% for phosphoric acid, 10.55% for thymine, 6.4% for cytosine and 9% and 7.7% for adenine and guanine respectively. Although there is no published report on the preparation of DEF