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目的 比较青蒿琥酯和奎宁治疗巴贝虫病的疗效. 方法 取感染田鼠巴贝虫的Nod-Scid种鼠血,经腹腔注射接种BALB/c小鼠.自接种后第4d开始,分别经口灌胃相同剂量的青蒿琥酯和奎宁.采用姬姆萨染色检查小鼠红细胞田鼠巴贝虫感染率,并检测小鼠的体温、体重、食量以及各项生理指标. 结果 在接种后第9d,各组小鼠红细胞田鼠巴贝虫感染率均达到高峰,但青蒿琥酯治疗组小鼠的红细胞染虫率(25.5％)低于奎宁治疗组(43.0％)和对照组(45.5％);在接种后第18 d各组小鼠红细胞染虫率均达到最低,青蒿琥酯治疗组小鼠的红细胞染虫率(2.5％)低于奎宁治疗组(6.0％)和对照组(6.5％),但不能清除红细胞内寄生的田鼠巴贝虫. 结论 青蒿琥酯抗巴贝虫效果优于奎宁,可以作为治疗巴贝虫病的候选药物.“,”Objective To compare artesunate and quinine as treatments for babesiosis.Methods BALB/c mice were intraperitoneally inoculated with 100 μl of blood infected with Babesia microti,which was collected,heparinized,and diluted with sterile saline to achieve a 30 ％ rate of RBC infection.After four days,the mice were treated with the same dose of artesunate or quinine via gavage;and mice in the control group received an equivalent volume of PBS.The percentage of RBCs infected with parasites and various physiological indices such as body temperature,weight,and appetite were determined for each mouse each day.Results On day 9 after inoculation,the percentage of RBCs infected with parasites peaked in all of the mice,but the percentage of RBCs infected with parasites in mice treated with artesunate (25.5 ％) was lower than that in mice treated with quinine (43.0％) or controls (45.5％).On day 18 after inoculation,the percentage of RBCs infected with parasites in all of the mice reached its nadir.The percentage of RBCs infected with parasites in mice treated with artesunate (2.5％) was significantly lower than that in mice treated with quinine (6.0％) or controls (6.5％).However,artesunate did not eliminate B.microti infecting RBCs.Conclusion Artesunate is more effective as a treatment for babesiosis than quinine,and artesunate may be a potential treatment for babesiosis.