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目的评价复方α-酮酸对慢性肾脏病(CKD)患者血压的影响。方法选择CKD3~5期非血液透析伴高血压患者64例,患者均低蛋白饮食,联合复方α-酮酸治疗(2.52 g/次,一日3次)6个月,比较治疗前后的血压,以及甲状旁腺素(PTH)和肾功能变化。结果 64例患者治疗后收缩压(SBP)和舒张压(DBP)及PTH均显著降低,但血清肌酐和尿素氮治疗前后相比差异无统计学意义。结论 CKD患者采用低蛋白饮食加复方α-酮酸治疗对血压控制可能有帮助。
Objective To evaluate the effect of compound α-keto acid on blood pressure in patients with chronic kidney disease (CKD). Methods Sixty-four patients with CKD stage 3-5 non-hemodialysis patients with hypertension were enrolled in this study. All patients were treated with low protein diet and combined with a-keto acid (2.52 g / time, three times a day) for 6 months. The blood pressure, As well as parathyroid hormone (PTH) and renal function changes. Results After treatment, SBP, DBP and PTH were significantly decreased in 64 patients, but no significant difference was found between serum creatinine and urea nitrogen before and after treatment. Conclusion CKD patients with low protein diet plus alpha-keto acid therapy may be helpful to control blood pressure.