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目的探讨一次性按需口服西地那非对特发性少弱精子症精液参数的影响。方法 2015年3月至2016年6月上海交通大学附属第一人民医院男科门诊采用动态均衡随机化方法收集特发性少弱精子症患者216例。初诊时经病史采集、体检后,按照WHO5行精液常规参数检测及相关检查,复诊时精液采集前0.5h给予西地那非50mg单次口服(禁欲3~5d),复查精液参数,观察精液参数变化,并问询服药过程中的不良反应。结果一次性按需口服西地那非前后精液体积、精浆生化、精子浓度、精子形态学无明显差异;用药后,前向运动精子百分比[(15.7±8.7)vs.(7.4±6.7)%,P<0.05]、前向精子运动总数[(12.2±9.1)×106 vs.(8.4±7.6)×106,P<0.05]明显改善。口服西地那非治疗期间,患者未出现明显严重不良反应。结论一次性按需口服西地那非可增加前向运动精子总数,改善部分少弱精子症患者精液参数。
Objective To investigate the effect of once-on-demand oral sildenafil on semen parameters of idiopathic oligoasthenospermia. Methods From March 2015 to June 2016, 216 outpatients with idiopathic oligoasthenospermia were recruited by the dynamic dynamic equilibrium randomization method from the First Affiliated Hospital of Shanghai Jiaotong University. The first visit when the history of the acquisition, physical examination, according to WHO5 routine sperm routine testing and related inspection, seizure referral before seizure 0.5h to give sildenafil 50mg single oral (abstinence 3 ~ 5d), review semen parameters to observe the semen parameters Change, and ask about the adverse reactions in the medication. Results There was no significant difference in seminal fluid volume, seminal plasma biochemistry, sperm concentration and sperm morphology before and after oral administration of oral sildenafil. After administration, the percentage of forward motile sperm [(15.7 ± 8.7) vs. (7.4 ± 6.7)% , P <0.05]. The total number of forward sperm motility [(12.2 ± 9.1) × 106 vs. (8.4 ± 7.6) × 106, P <0.05] was significantly improved. During the course of oral sildenafil treatment, there was no apparent serious adverse reaction. Conclusions One-time oral administration of sildenafil can increase the total number of sperm motile forward and improve sperm parameters of some oligospermic patients.