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γ-氨基丁酸(GABA)是哺乳动物脑中主要的抑制性神经介质。在兔的暴发性肝功衰竭模型中,证实了肠道细菌是循环中GABA的主要来源。在肝性脑病综合症中,GABA神经介质系统参与并介导了抑制性神经活动。作者对此作了检测。方法共检测了145例急、慢性肝细胞性疾病患者和22例正常对照。血清中GABA样活性的测
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain. In the rabbit model of fulminant hepatic failure, it was demonstrated that gut bacteria are the main source of circulating GABA. In Hepatic Encephalopathy Syndrome, GABA neurotransmitter systems are involved and mediate inhibitory neural activity. The author made this test. Methods A total of 145 patients with acute and chronic hepatocellular diseases and 22 normal controls were detected. Determination of serum GABA-like activity