本研究小组前期以抑制性差减杂交技术筛选肥胖与健康人腹膜后脂肪组织中的差异表达基因,结果发现一条新基因在肥胖患儿脂肪组织中表达量明显升高,将其命名为NYGGF4。2006年以来本研究小组致力于该基因的功能研究,系统、全面地研究了该基因的生物学特性及功能,基因表达、调控的特点,现将这些系列研究进展作一综述。 Our team used suppression subtractive hybridization screening of differentially expressed genes in obese and healthy human retroperitoneal adipose tissue in early stage and found that a new gene was significantly increased in adipose tissue of obese children and named it NYGGF4.2006 Since the beginning of this year, the research team has devoted itself to the functional study of this gene and has systematically and comprehensively studied the biological characteristics, functions, gene expression and regulation of this gene. The progress of these series of researches is summarized.