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目的:探讨不同剂量的超微左金丸与传统左金丸对大鼠慢性胃炎的药效作用。方法:采用水杨酸钠结合饥饱失常等方法制成大鼠慢性胃炎模型,将造模成功的60只大鼠随机分为6组,即传统高、低剂量组(0.216g/mL、0.108g/m L),超微高、低剂量组(0.108g/mL、0.054g/mL),对照药组(0.00036g/mL奥美拉唑),模型组,并设空白组,每组10只。连续灌胃给药2周,每次每只2mL,每天1次,模型组继续给予水杨酸钠造模,空白组给予同等剂量的0.9%氯化钠注射液。用药后对大鼠胃酸、胃蛋白酶活性、血清SOD活力、MDA值以及病理切片进行比较分析。结果:与空白组比较,模型组胃液p H值和胃蛋白酶活性升高、血清SOD活力降低、MDA含量升高,差异均有统计学意义(P<0.05);与模型组比较,超微和传统左金丸均可降低胃液p H值和胃蛋白酶活性、升高血清SOD活力、降低MDA含量,差异有统计学意义(P<0.05),同时从病理切片结果显示其对胃黏膜有修复作用。结论:超微左金丸和传统左金丸对大鼠慢性胃炎有很好的效果,超微左金丸用量少、疗效优、使用方便,值得推广应用。
Objective: To investigate the effect of different doses of Zuoganjinwan and traditional Zuojinwan on chronic gastritis in rats. Methods: A rat model of chronic gastritis was established by using sodium salicylate combined with starvation insufficiency and other methods. 60 successful rats were randomly divided into 6 groups: traditional high and low dose groups (0.216g / mL, 0.108 (0.108g / mL, 0.054g / mL), the control group (0.00036g / mL omeprazole), model group, and blank control group only. The rats in the model group were given sodium salicylate continuously and the blank group were given the same dose of 0.9% sodium chloride injection for 2 weeks. After treatment, gastric acid, pepsin activity, serum SOD activity, MDA value and pathological sections were compared and analyzed. Results: Compared with the blank group, p H value and pepsin activity of gastric juice increased, serum SOD activity decreased and MDA content increased in model group (P <0.05). Compared with model group, Traditional Zuojin Pills could reduce p H value and pepsin activity in gastric juice, increase serum SOD activity and decrease MDA content, the difference was statistically significant (P <0.05). Meanwhile, the results of pathological examination showed that it could repair gastric mucosa. Conclusion: ZJJN and ZQJJ have good effect on chronic gastritis in rats. The dosage of ZJJN is less, the curative effect is superior, and it is convenient to use. It is worth to be popularized and applied.