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二甲双胍广泛用于非胰岛素依赖型糖尿病(NIDDM)用磺脲类治疗血糖控制不佳者。尽管胰岛素可以较好地控制血糖,但所需剂量通常很大,目前认为 NIDDM 的大血管病可能与胰岛素剂量有关。据此,二甲双胍提供了一种替代治疗的选择。本文拟阐述加用二甲双胍的临床效用,血糖控制的改善与脂质代谢变化的关系和生理学变化。材料与方法:13例 NIDDM 病人(10名男性,3名女性)年龄57±2岁,在用美吡哒40mg/d 治疗6～8周后空腹血糖仍保持在10mmol/L 以上时开始加用二甲双胍。治疗前后测定空腹和8时～16时之间每小时的血糖、FFA、胰岛素、甘油三酯(TG)。也测定糖化血红蛋白,并采空腹血以测
Metformin is widely used in non-insulin-dependent diabetes mellitus (NIDDM) with sulfonylureas to control poor glycemic control. Although insulin can better control blood sugar, but the required dose is usually large, now that the NIDDM macrovascular disease may be related to insulin dosage. Accordingly, metformin provides an alternative treatment option. This article describes the clinical utility of adding metformin, the improvement of glycemic control and changes in lipid metabolism and physiological changes. MATERIALS AND METHODS: Thirteen NIDDM patients (10 males and 3 females) were 57 ± 2 years of age and started to receive fasting blood glucose at 10 mmol / L after 6-8 weeks of treatment with 40 mg pyridoxine Metformin. Blood glucose, FFA, insulin, and triglyceride (TG) were measured hourly before and after treatment between 8 and 16 o’clock. Also measured glycated hemoglobin, and take fasting blood to measure