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本文采用图像分析系统对喉乳头状瘤伴上皮不典型增生及喉鳞状细胞癌进行了细胞核形态定量学研究 :同时检测了细胞核的DNA含量。结果显示 :随鳞状上皮不典型增生程度加重及喉癌的出现 ,细胞核形态学参数 (核面积、核长径、核周长及核圆度 )逐渐增加 ,重度不典型增生和癌变之间存在明显界限 ;并且核面积与DNA含量之间具有明显的正相关关系。提示 :本方法对早期发现喉的癌前病变及癌提供了一种客观有效的形态学诊断依据 ,具有一定的临床实用价值。
In this paper, image analysis system for laryngeal papilloma with epithelial atypical hyperplasia and laryngeal squamous cell carcinoma of the nucleus morphology quantitative study: simultaneous detection of the nucleus DNA content. The results showed that with the increasing degree of atypical hyperplasia of squamous epithelium and the appearance of laryngeal carcinoma, nuclear morphological parameters (nuclear area, nuclear long axis, nuclear perimeter and nuclear roundness) increased gradually, and between severe dysplasia and carcinogenesis Obvious boundaries; and nuclear area and DNA content has a significant positive correlation between. Tip: This method provides an objective and effective basis for morphological diagnosis of early detection of laryngeal precancerous lesions and cancers, and has certain clinical practical value.