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报告1例原位型乳头状汗管囊腺癌。患者男,64岁。腰部斑块10年,增大1年。皮肤科检查:腰部一直径约10 cm斑块,颜色淡红,表面潮湿、不光滑,触之较硬。皮损组织病理检查:表皮角化过度伴角化不全,浆痂形成,部分表皮向下凹陷形成囊腔样结构,可见乳头状突起,囊壁由复层鳞状上皮构成,细胞排列紊乱,部分细胞核大深染,可见病理性核分裂象,间质内见大量浆细胞。免疫组化检查:癌胚抗原(CEA)、上皮膜抗原(EMA)、角蛋白(CK)7陷窝处局灶阳性,核增殖抗原(Ki-67)约60%阳性,P63阳性,巨囊病性液体蛋白(GCDFP)-15阴性,诊断:原位型乳头状汗管囊腺癌。
Report 1 case of papillary cystadenocarcinoma in situ. Patient male, 64 years old. Waist plaque 10 years, an increase of 1 year. Dermatology examination: a diameter of about 10 cm waist patch, color pink, wet surface, not smooth, touch harder. Skin lesions histological examination: epidermal hyperkeratosis with parakeratosis, the formation of plasma callus, part of the epidermis down to form a cystic cavity structure, visible papillary protrusions, the cyst wall by stratified squamous epithelium, the cells arranged in disorder, part of the Large deep staining of the nucleus, visible pathological mitosis, see a large number of interstitial plasma cells. Immunohistochemical examination showed that CEA, EMA, and focal sites in 7 lobes of keratin were positive, Ki-67 was about 60% positive, P63 was positive, Disease fluid protein (GCDFP) -15 negative, diagnosis: in situ papillary cystadenocarcinoma.