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大量的证据表明 ,脑循环对内皮素 (ＥＴ)的作用非常敏感[1] ,在蛛网膜下腔出血 (ＳＡＨ)后的病理性脑血管表现出稳定的、持久的缩血管作用。[2～ 6] 。随着研究的深入 ,人们发现ＥＴ - 1是通过和血管平滑肌细胞膜上的受体结合后激活平滑肌细胞膜上的一系列信号传递系统而起作用
There is ample evidence that the cerebral circulation is very sensitive to the effects of endothelin (ET) [1] and that the pathological cerebral vessels after subarachnoid hemorrhage (SAH) exhibit a stable, long-lasting vasoconstrictor effect. [2 ~ 6]. With the deepening of research, ET - 1 has been found to act by activating a series of signaling systems on the smooth muscle cell membrane by binding to receptors on vascular smooth muscle cells