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[目的]探讨缺氧诱导因子-1α蛋白(HIF-1α)在乳腺癌中的表达情况及其与乳腺癌临床特征和预后的关系。[方法]选择56例女性原发性乳腺癌患者的癌组织标本。采用免疫组化法检测癌组织中HIF-1α蛋白的表达状况,分析HIF-1α蛋白表达与各临床特征以及乳腺癌预后的相关性。[结果]HIF-1α蛋白在乳腺癌组织中的阳性表达率(73.2%)及高表达率(41.1%)均明显高于乳腺良性肿瘤组织(P<0.05)。HIF-1α蛋白表达与乳腺癌淋巴结转移、病理学分期及组织学分级有关(P<0.05)。乳腺癌组织中HIF-1α高表达病例5年存活率为29.2%,明显低于HIF-1α低表达病例(81.2%)(P=0.000)。HIF-1α蛋白与Her-2蛋白同时阳性组的患者预后最差(P<0.0001)。[结论]乳腺癌组织中HIF-1α的高表达与预后差、生存期短有关,HIF-1α的高表达是乳腺癌的危险因素,有助于判断肿瘤的侵袭性和转移能力。HIF-1α蛋白与Her-2蛋白均为乳腺癌的影响因素,在乳腺癌的进展中可能具有协同作用。
[Objective] To investigate the expression of hypoxia-inducible factor-1α (HIF-1α) in breast cancer and its relationship with the clinical features and prognosis of breast cancer. [Method] Choose 56 cases of female patients with primary breast cancer samples. Immunohistochemistry was used to detect the expression of HIF-1α in cancer tissues. The correlation between the expression of HIF-1α protein and clinical features and the prognosis of breast cancer was analyzed. [Results] The positive expression rate of HIF-1α in breast cancer tissues (73.2%) and high expression rate (41.1%) were significantly higher than those in benign breast tumors (P <0.05). HIF-1αprotein expression was correlated with lymph node metastasis, pathological staging and histological grade in breast cancer (P <0.05). The 5-year survival rate of HIF-1α overexpression was 29.2% in breast cancer tissues, which was significantly lower than that of HIF-1α low expression (81.2%) (P = 0.000). Patients with a positive HIF-1α protein and a Her-2 protein had the worst prognosis (P <0.0001). [Conclusion] The high expression of HIF-1α in breast cancer is associated with poor prognosis and short survival. The high expression of HIF-1α is a risk factor for breast cancer, which helps to determine the invasive and metastatic potential of the tumor. Both HIF-1α protein and Her-2 protein are the influencing factors of breast cancer, which may have a synergistic effect on the progress of breast cancer.