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由于实验免疫学技术的不断发展,人们对免疫活性细胞的分化和机能活动的认识也逐渐深入.一般情况下,T和B淋巴细胞在形态上难以区别;但在免疫反应中,二者在分化、繁殖上显示了区别.Fagraeus(1948)首先阐明,在抗原刺激下,B淋巴细胞可以分化为产生抗体的浆细胞).Coons等(1955)和Leduc等(1955、1968)用免疫荧光技术证明了在免疫反应中淋巴母细胞、浆母细胞和浆细胞中的特异性抗体成分.Balfour等(1965)应用放射自显影技术证明,部分大的嗜硷性母细胞,浆母细胞和浆细胞以及部分小淋巴细胞
Due to the continuous development of experimental immunology technology, people’s understanding of the differentiation and functional activity of immunocompetent cells is also gradually deepened.Generally, T and B lymphocytes are indistinguishable morphologically, but in the immune response, both are differentiated , Fagraeus (1948) first demonstrated that B lymphocytes can differentiate into antibody-producing plasma cells under antigen stimulation.) Coons et al. (1955) and Leduc et al. (1955, 1968) demonstrated by immunofluorescence Balbour et al. (1965) applied autoradiography to demonstrate that some of the large alkalophilic blasts, plasmablasts, and plasma cells, as well as Some small lymphocytes