为了解轻型哮喘患者的病理学特征,作者选择无症状哮喘患者8例,其 FEV_1最低值为70%,所有患者在试验两周前肺功能稳定。正常对照者4名。患者作支气管镜检查,并作支气管灌洗及活检。6h 后以乙酰甲胆碱或变应原作激发试验。激发试验8h 后,再施支气管镜检查,并作支气管灌洗与活检。支气管镜检查后2～3周,作组胺激发试验。 To understand the pathological features of patients with mild asthma, the authors selected 8 patients with asymptomatic asthma with a minimum FEV 1 of 70%. All patients had stable lung function two weeks prior to the test. Normal control 4. Patients for bronchoscopy, and for bronchial lavage and biopsy. 6h after methacholine or allergen for the challenge test. After 8h excitation test, bronchoscopy was performed and bronchial lavage and biopsy were performed. Bronchoscopy 2 to 3 weeks after the test for histamine excitation.