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目的：研究癌基因在皮肤Ｔ细胞淋巴瘤中的作用。方法：采用免疫组织化学技术检测了３２例蕈样肉芽肿／Ｓéｚａｒｙ综合征（ＭＦ／ＳＳ）皮肤组织中癌基因ｒａｓ和ｍｙｃ蛋白产物ｐ２１和ｐ６２的表达。结果：３２例ＭＦ／ＳＳ中有１２例ｐ２１阳性，有１７例ｐ６２阳性，有１０例同时示ｐ２１和ｐ６２阳性。其中有皮肤外播散的进展期ＭＦ／ＳＳ比局限于皮肤的早期ＭＦ／ＳＳ增高明显。结论：ｐ２１ｐａｎｒａｓ和ｐ６２ｃｍｙｃ的表达，与ＭＦ／ＳＳ细胞增殖转化相关。ｒａｓ和ｍｙｃ癌基因可能在ＭＦ／ＳＳ的多阶段发病过程中起协同作用。
Objective: To study the role of oncogene in cutaneous T-cell lymphoma. Methods: Immunohistochemical technique was used to detect the expression of oncogene ras and myc protein p21 and p62 in 32 cases of granuloma/Sézary syndrome (MF/SS). RESULTS: Of the 32 MF/SS cases, 12 were p21 positive, 17 were p62 positive, and 10 were positive for p21 and p62. Among these, advanced MF/SS over skin dissemination was significantly higher than early MF/SS that was limited to the skin. Conclusion: The expression of p21pan ras and p62cmyc is related to the proliferation and transformation of MF/SS cells. The ras and myc oncogenes may play a synergistic role in the multistage development of MF/SS.