Small ubiquitin-related modifier(SUMO)是一类重要的类泛素蛋白,其修饰过程与泛素类似,但功能不尽相同,SUMO通过对底物蛋白的修饰来调节蛋白间的相互作用、定位及稳定性等功能。近年来,包括一些病毒蛋白在内的大量底物蛋白陆续被发现,SUMO化作为一种重要的蛋白质翻译后修饰,在病毒对宿主细胞的感染中既可发挥促进病毒感染的作用,也可发挥抑病毒感染的作用。 Small ubiquitin-related modifier (SUMO) is a kind of important ubiquitin protein. Its modification process is similar to ubiquitin, but its function is different. SUMO regulates the interaction between protein and its localization through the modification of substrate protein Stability and other functions. In recent years, a large number of substrate proteins, including some viral proteins, have been successively discovered. As an important protein post-translational modification, SUMOylation can play a role of promoting virus infection in virus infection of host cells, The role of virus infection.