目的了解山西省晋城市手足口病的流行特征及其变化。方法采用描述流行病学方法对2008-2011年晋城市手足口病疫情监测资料进行分析。结果 2008-2011年晋城市共报告手足口病3302例,年均发病率为36.50/10万,无死亡病例,不同年份间发病率差异有统计学意义(P<0.005),以2009年发病率最高。全市6个县(市、区)均出现不同程度的流行,以城区和高平市为主。发病呈双峰型,主要集中在5-7月和10-12月。年龄以5岁以下儿童为主,男性多于女性。患者多为散居儿童和幼托儿童。病原体以柯萨奇病毒A组16型(Coxsackievirus A16,Cox A16)和肠道病毒71型(human Enterovirus 71,EV71)并存。结论晋城市手足口病的发生存在明显的地区、etiological diagnosis季节、性别及年龄差异。 Objective To understand the epidemiological characteristics and changes of hand-foot-mouth disease in Jincheng City of Shanxi Province. Methods Epidemiological methods were used to analyze the monitoring data of HFMD in Jincheng City from 2008 to 2011. Results A total of 3302 HFMD cases were reported in Jincheng City from 2008 to 2011, with an average annual incidence rate of 36.50 / 100 000 and no deaths. The incidence rates of different years were significantly different (P <0.005) highest. The city’s six counties (cities, districts) have emerged in varying degrees of popularity, mainly in urban areas and the city of Gaoping. The incidence was bimodal, mainly concentrated in May-July and October-December. The majority of children under 5 years old are men and more than women. Patients are mostly diaspora and kindergarten children. The pathogens coexisted with Coxsackievirus A16 (Cox A16) and enterovirus 71 (EV71). Conclusions The occurrence of hand, foot and mouth disease in Jincheng City is obvious. The etiological diagnosis shows seasonal, gender and age differences.