论文部分内容阅读
本文报告对局限性小细胞肺癌常规剂量化疗后行强化化疗合并放疗的Ⅱ期临床研究。接受大剂量环磷酰胺、顺铂、卡氮芥与自身骨髓移植联合治疗的Ⅲ期小细胞肺癌的成年患者19例,对首次常规化疗至少部分有效。三种药物的累积剂量分别为6625,165及480mg/m~2。恢复后进行胸腔放疗(50～60Gy,分25～30次,5～6周以上)及头部放疗(30Gy,分15次,3周)。大剂量化疗后,19例中15例
This article reports a phase II clinical study of intensive chemotherapy plus radiotherapy for patients with localized small cell lung cancer after conventional dose chemotherapy. Nineteen adult patients with stage III small cell lung cancer treated with large doses of cyclophosphamide, cisplatin, carmustine and autologous bone marrow transplantation were at least partially effective for the first time conventional chemotherapy. The cumulative doses of the three drugs were 6625, 165 and 480 mg/m2, respectively. After recovery, chest radiotherapy (50-60 Gy, 25-30 times, 5-6 weeks) and head radiotherapy (30 Gy, 15 times, 3 weeks) were performed. After high-dose chemotherapy, 15 of 19 cases