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采用Ｏ１１１Ｂ４大肠杆菌腹腔注射的方法诱发大鼠实验性腹膜炎，按Ｌ８（２７）正交设计法观察腑安冲剂及其组分对实验性腹膜炎大鼠内毒素血症的影响及对肺脏的保护作用。结果显示：腑安冲剂及其组分能降低外周血内毒素、肿瘤坏死因子及肺组织丙二醛的含量，并有增加肺组织谷胱甘肽含量及降低肺系数、肺灌洗液中蛋白含量及白细胞数等显著作用。经多指标同步分析表明：用腑安冲剂治疗腹膜炎、内毒素血症及减轻肺损伤以全方为最佳组方，从而进一步论证了用药处方的合理性与科学性。
Experimental peritonitis was induced by intraperitoneal injection of O111B4 in E. coli. The effects of Fuan granules and its components on endotoxemia in experimental peritonitis rats and its protective effect on lungs were observed by L8 (27) orthogonal design . The results showed that Fuan granules and its components can reduce the contents of endotoxin, tumor necrosis factor, and malondialdehyde in lung tissue, increase the glutathione content in lung tissue and decrease the pulmonary coefficient, and the protein in lung lavage fluid Content and the number of white blood cells and other significant role. Simultaneous analysis of multiple indicators showed that the treatment of peritonitis, endotoxemia and lung injury with Fugan granules was the best prescription, which further demonstrated the rationality and scientificity of prescriptions.