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[目的]探讨颅脑外伤后患者血浆渗透压水平变化的临床意义。[方法]回顾性分析某院神经外科2007年10月～2010年10月期间收治的125例颅脑外伤患者的临床资料,根据入院格拉斯哥评分将患者分为3组,分别测定患者血浆渗透压、血钠、血糖及血尿素氮,比较3组患者血浆渗透压水平,并对血浆渗透压与血钠、血糖及血尿素氮进行线性回归分析,患者出院时按GOS进行疗效判定,分析血浆渗透压与疾病预后的关系。[结果]患者颅脑外伤病情越严重,血浆渗透压越高,且血浆渗透压水平与血钠、血糖、血尿素氮呈正性相关,住院期间死亡、重残及植物生存状态患者的血浆渗透压水平显著高于治愈及中残患者,差异均有统计学意义(P﹤0.05)。[结论]颅脑外伤患者血浆渗透压水平可作为反映疾病严重程度的客观指标,监测其变化可作为患者病情变化和判断预后的可靠指标,临床上可通过纠正或改善患者血浆渗透压改善患者预后。
[Objective] To investigate the clinical significance of plasma osmotic pressure in patients with craniocerebral trauma. [Methods] The clinical data of 125 patients with traumatic brain injury admitted to our hospital from October 2007 to October 2010 were retrospectively analyzed. The patients were divided into 3 groups according to the Glasgow score, and the plasma osmotic pressure, Blood sodium, blood glucose and blood urea nitrogen. Plasma levels of osmotic pressure were compared between the three groups. Linear regression analysis was performed between plasma osmolality and serum sodium, blood glucose and blood urea nitrogen. The patients were discharged according to GOS and the plasma osmolality And disease prognosis. [Results] The more severe the traumatic brain injury patients were, the higher the osmotic pressure was. And the plasma osmolality level was positively correlated with serum sodium, blood sugar and blood urea nitrogen, and the plasma osmotic pressure in hospitalized patients died of severe disability and vegetative state The levels were significantly higher than those of cured and moderately disabled patients, the differences were statistically significant (P <0.05). [Conclusion] The level of plasma osmotic pressure in patients with craniocerebral trauma can be used as an objective index to reflect the severity of the disease. Monitoring the changes can be used as a reliable indicator of patient’s condition and prognosis. Clinically, it can improve the prognosis of patients by correcting or improving the plasma osmotic pressure .