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目的研究胰岛素样生长因子3(IGFBP-3)、碱性成纤维细胞生长因子(bFGF)、核增殖抗原(Ki-67)蛋白在非小细胞肺癌(NSCLC)中的表达及意义。方法应用免疫组化技术对60例NSCLC组织中IGFBP-3、bFGF、Ki-67抗原表达进行检测和分析。结果IGFBP-3、bFGF和Ki-67抗原表达率分别为71.67%(43/60)、56.67%(34/60)和68.33%(41/60);IGFBP-3和Ki-67表达与肿瘤分化程度、分期及淋巴结转移有关(P<0.05);bFGF表达与淋巴结转移及分期有关(P<0.05),与肿瘤的分化程度无关;三种标记的阳性表达与年龄、性别、组织类型无显著相关性(P>0.05)。IGFBP-3和bFGF、Ki-67的表达呈负相关(P<0.05)。结论在NSCLC组织中检测IGFBP-3、bFGF、Ki-67的表达对于判断NSCLC患者预后具有重要意义。
Objective To study the expression and significance of IGFBP-3, bFGF and Ki-67 in non-small cell lung cancer (NSCLC). Methods The expressions of IGFBP-3, bFGF and Ki-67 in 60 NSCLC tissues were detected by immunohistochemistry. Results The positive rates of IGFBP-3, bFGF and Ki-67 were 71.67% (43/60), 56.67% (34/60) and 68.33% (41/60), respectively. The expressions of IGFBP-3 and Ki- (P <0.05). The expression of bFGF was correlated with the lymph node metastasis and stage (P <0.05), but not with the degree of tumor differentiation. There was no significant correlation between the expression of bFGF and the age, sex and histological type (P> 0.05). IGFBP-3 and bFGF, Ki-67 expression was negatively correlated (P <0.05). Conclusion The detection of IGFBP-3, bFGF and Ki-67 expression in NSCLC is of great significance in judging the prognosis of patients with NSCLC.