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药代动力学是研究药物在动物体内吸收代谢过程中一系列降解、吸收,排泄中的化学反应速度及化学平衡问题。由这一系列生化反应过程中所得到的系列药动学参数如吸收速率、消除速率、半衰期、曲线下面积等可以定量的反映药物在临床使用中应当注意的一些重要问题,为安全用药与合理用药提出可靠的理论数据。但是由于药物在动物体内经过吸收、降解之后,血液中存在的原药物浓度较低,必须采用非常灵敏的测定方法,才能达到监测的目的,而高灵敏的发光技术则是进行血药浓度临测的重要手段之一。
Pharmacokinetics is to study the chemical reaction speed and chemical balance of a series of degradation, absorption and excretion in the absorption and metabolism of drugs in animals. The series of pharmacokinetic parameters such as absorption rate, elimination rate, half-life, area under the curve obtained from the series of biochemical reactions can quantitatively reflect some important issues that should be noticed in the clinical use of drugs, for safe medication and reasonable Medication put forward reliable theoretical data. However, due to the absorption and degradation of the drug in the animal, the concentration of the original drug present in the blood is relatively low, and a very sensitive measurement method must be adopted in order to achieve the purpose of monitoring. The highly sensitive luminescence technique is to perform the blood concentration measurement One of the important means.