论文部分内容阅读
目的观察异甘草酸镁注射液治疗肝功能异常的临床疗效。方法 72例肝功能异常患者,随机分为治疗组(40例)和对照组(32例)。治疗组给予异甘草酸镁治疗,对照组给予复方甘草酸苷治疗。两组均治疗4周。观察两组患者临床症状、体征、肝功能变化及不良反应。结果两组患者的临床症状、体征均有明显改善,且治疗组复常时间少于对照组(P<0.05);治疗组谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)复常率分别为92.5%、90.0%、97.5%,对照组分别为90.6%、87.5%、84.4%,两组比较差异无统计学意义(P>0.05);两组复常时间对比,差异有统计学意义(P<0.05);治疗组未发生明显不良反应,而对照组发生2例不良反应。结论异甘草酸镁注射液可明显改善肝功能异常患者的临床症状和肝功能指标,临床应用安全有效,可推广应用。
Objective To observe the clinical effect of magnesium glycyrrhizinate injection on liver dysfunction. Methods 72 patients with abnormal liver function were randomly divided into treatment group (40 cases) and control group (32 cases). The treatment group was given magnesium isoglycyrrhizinate, while the control group was given compound glycyrrhizin. Both groups were treated for 4 weeks. The clinical symptoms, signs, changes of liver function and adverse reactions in the two groups were observed. Results The clinical symptoms and signs of both groups were significantly improved, and the recovery time of the treatment group was less than that of the control group (P <0.05). The levels of ALT, AST and total bilirubin TBIL) were 92.5%, 90.0% and 97.5% respectively, while the control group was 90.6%, 87.5% and 84.4% respectively, there was no significant difference between the two groups (P> 0.05) The difference was statistically significant (P <0.05); no significant adverse reactions in the treatment group, while two cases of adverse reactions in the control group. Conclusion Magnesium isrimazole injection can significantly improve the clinical symptoms and liver function in patients with abnormal liver function. The clinical application is safe and effective and can be extended and applied.