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目的探讨小肠原发性鳞状细胞癌的临床及病理学特征。方法通过组织病理学及免疫组化方法对1例小肠原发性鳞状细胞癌进行观察,探讨其发病机制并复习相关文献。结果 1例发生于近端回肠的鳞状细胞癌,其病理组织学特征与发生于其他部位(宫颈、食道、皮肤)的鳞状细胞癌相同,并可找到鳞状细胞癌与正常小肠黏膜腺上皮之间的移行过渡区。免疫组化:肿瘤细胞34βE12、AE1/AE3、CK5/6和p63(),CK20、NSE、Syn和CgA(-)。结论原发于小肠的鳞状细胞癌非常罕见,需与继发性鳞癌、腺鳞癌、类癌及其他神经内分泌癌等相鉴别,其发病机制尚不清楚,可能与腺上皮细胞鳞化进而继发性恶变有关。
Objective To investigate the clinical and pathological features of small intestine primary squamous cell carcinoma. Methods One case of primary primary squamous cell carcinoma of the small intestine was observed by histopathology and immunohistochemistry. The pathogenesis of the disease and the related literature were reviewed. Results One case of squamous cell carcinoma of the proximal ileum had the same histopathological features as squamous cell carcinoma in other sites (cervix, esophagus and skin), squamous cell carcinoma and normal intestinal mucosa Transition between epithelial transitional zone. Immunohistochemistry: tumor cells 34βE12, AE1 / AE3, CK5 / 6 and p63 (), CK20, NSE, Syn and CgA (-). Conclusion Primary squamous cell carcinoma of the small intestine is very rare and needs to be differentiated from secondary squamous cell carcinomas, adenosquamous carcinomas, carcinoids and other neuroendocrine carcinomas. The pathogenesis of squamous cell carcinomas is unclear and may be related to the scaling of glandular epithelial cells Then secondary malignant transformation.