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无论何种烧伤,其面积超过体表面积的10～15%就会引起全身和局部的生理反应。烧伤发生的病理生理变化,包括心血管变化,肝、肾功能变化和血浆蛋白浓度变化,均能改变药物的体内过程。影响药代动力学的病理生理变化心血管因素:烧伤病人的临床过程可分为两个不同的代谢期。急性期(或复苏期),刚烧伤后,组织器官的血流减少。包括低血容量在内的许多因素都抑制心肌功能,增加血液粘滞度以及释放血管活性物质,促使血流减少。因此,该期经皮下或肌肉注射的药物吸收延迟,药物的峰值浓度和
No matter what kind of burn, the area of more than 10 to 15% of body surface area will cause systemic and local physiological response. Pathophysiological changes in the occurrence of burns, including cardiovascular changes, liver and kidney function changes and changes in plasma protein concentrations, can change the drug’s in vivo process. Pathophysiological changes affecting pharmacokinetics Cardiovascular factors: The clinical course of burn patients can be divided into two distinct metabolic phases. Acute phase (or recovery period), just after burn, tissue and blood flow to reduce. Many factors, including hypovolemia, inhibit myocardial function, increase blood viscosity, and release vasoactive substances, resulting in reduced blood flow. Therefore, the period of subcutaneous or intramuscular drug absorption delay, peak drug concentration and